editor@radiologiamedicajournal.com
editor@radiologiamedicajournal.com
Nisreen Mohammed Helmi¹, Abeerah Khalid Albokhari², Lamir Hassan Meriky³, Atheer Fahad Alshaikh⁴, Abdullah Alhussain Alraqdi³, Khulud Khalid Mahmoud⁴, Almuhannad Meshal Alzahrani⁵, Abdullah Awad Alharthi³, Bashaer Mohammed Alotaibi⁴, Fahad Helal Alsafari⁴
Ultrasound-guided drug delivery (UGDD) and therapeutic ultrasound (TUS) have emerged as innovative approaches for improving the efficacy, specificity, and safety of pharmacological interventions. By leveraging acoustic energy, these modalities enable spatially and temporally controlled drug release, facilitate targeted delivery, and reduce systemic toxicity. This review consolidates recent advances, focusing on mechanisms such as cavitation, sonoporation, acoustic radiation force, and thermal effects; novel ultrasound-responsive nanocarriers including liposomes, micelles, nanobubbles, and phase-change droplets; and the current status of clinical translation. Preclinical and early clinical studies highlight promising therapeutic outcomes and the potential for personalized treatment. Despite these advances, challenges remain in standardizing ultrasound parameters, optimizing nanocarrier design, ensuring safety, and navigating regulatory pathways. Addressing these challenges is essential for bridging the gap between bench research and clinical application.
Keywords:
Ultrasound-guided drug delivery; therapeutic ultrasound; nanocarriers; microbubbles; sonoporation; clinical translation.
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